Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
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منابع مشابه
Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.
The evolution of Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi outer surface proteins (Osps) A or B was assessed to investigate the role of immunity to OspA or B in infection and pathogenesis of Lyme disease. Antibodies to OspA or B protect immunocompetent C3H/HeJ or C.B.17 severe combined immunodeficient (scid) mice from challenge with B. burgdorferi. Moreover, arthritis...
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Antibody responses to outer surface protein A (OspA) of Borrelia burgdorferi may occur during periods of arthritis late in the clinical course of untreated Lyme disease. These antibody responses are paradoxical, given the conclusive evidence demonstrating that B. burgdorferi transmitted to the mammalian host expresses little or no OspA. The parallel occurrence of OspA antibodies and arthritic e...
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متن کاملBorrelia burgdorferi (Lyme Disease)
Lyme disease is the most common vector-borne disease in the United States. In the United States, the spirochete Borrelia burgdorferi sensu stricto (hereafter termed B burgdorferi) is the only pathogen that causes Lyme disease. However, in Europe and Asia, Borrelia afzelii, Borrelia garinii, and other related species, in addition to B burgdorferi, cause Lyme disease. In the United States, these ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1995
ISSN: 0021-9738
DOI: 10.1172/jci118215